The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition
نویسنده
چکیده
The continuing debate over the basis of odorant recognition with respect to the molecular shape ("lock and key") theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster.
منابع مشابه
Evaluation of gustatory and olfactory function among premenopausal and postmenopausal women and men
BACKGROUND AND AIM: The sense of taste is a chemical sense which allows everyone to perceive the flavor of what is eaten or drunk. Also, the sense of olfaction is also a chemical sense contributing to the sense of taste to perceive the taste and flavor of food. In the present work, the gustatory and olfactory function in pre- and postmenopausal women and men were studied and compared to each ot...
متن کاملThe Factors Associated With Olfactory Dysfunction in Patients with Multiple Sclerosis
Introduction: An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease. In this study, we assessed the olfactory function in patients with Multiple Sclerosis (MS) by Sniff Magnitude Test (SMT). Methods: A cross-sectional study was conducted on 48 patients with MS. A questionnaire, including demog...
متن کاملTheory of mind and its neural mechanisms: A case study of Kurdish-Persian congenitally blind children in Ilam city
Introduction: Theory of mind is one of the most important aspects of cognitive faculty. The theory of mind is impaired in individuals who suffer from mental disorders like autistic children. The ‘autistic-like’ behaviors also have been reported in the congenitally blind children. This study was conducted to examine the presence or absence of theory of mind and its function in congen...
متن کاملValidation of Shell Theory for Modeling the Radial Breathing Mode of a Single-Walled Carbon Nanotube (RESEARCH NOTE)
In this paper, the radial breathing mode (RBM) frequency of single-walled carbon nanotube (SWCNT) is studied based on the thin shell theory. For this purpose, SWCNT is considered as an elastic thin cylindrical shell. The dynamic equation of RBM is derived using the Hamilton’s principle. An analytical solution of the RBM frequency of SWCNT is obtained. The advantage of this formulation is that i...
متن کاملImplausibility of the vibrational theory of olfaction.
The vibrational theory of olfaction assumes that electron transfer occurs across odorants at the active sites of odorant receptors (ORs), serving as a sensitive measure of odorant vibrational frequencies, ultimately leading to olfactory perception. A previous study reported that human subjects differentiated hydrogen/deuterium isotopomers (isomers with isotopic atoms) of the musk compound cyclo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013